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Umactin 50mg Capsule 1 Strip
Umactin (Nitrofurantoin)
Class: Antibiotic (Nitrofuran derivative)
Indication: Treatment and prevention of uncomplicated urinary tract infections (UTIs)
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✅ Description:
Nitrofurantoin works by disrupting bacterial cell metabolism and inhibiting cell wall synthesis. It targets several bacterial enzyme systems, including acetyl coenzyme A, exerting a bactericidal effect against most Gram-positive and Gram-negative uropathogens.
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✔️ Side Effects of Umactin 50
- Common Side Effects
- Gastrointestinal: Nausea, vomiting, diarrhea, anorexia, abdominal discomfort
- CNS: Drowsiness, dizziness, headache, vertigo
- Dermatologic: Rash, pruritus, urticaria
- Urine discoloration: Brown or dark yellow urine (benign)
Serious and Rare Side Effects
Potentially Fatal:
- Peripheral neuropathy
- Hepatotoxicity
- Pulmonary fibrosis, interstitial pneumonitis
- Stevens-Johnson syndrome, anaphylaxis
- Hematologic disorders: Aplastic anemia, hemolytic anemia (especially in G6PD-deficient patients), agranulocytosis
✔️ Indication of Umactin 50
- Acute uncomplicated urinary tract infections (cystitis)
- Prophylaxis of recurrent uncomplicated UTIs
✔️ Patient Guidance
- Take with food to reduce nausea.
- Complete the full course even if symptoms improve early.
- Do not use if pregnant at term or if breastfeeding a newborn.
- Urine discoloration is normal and harmless.
- Report any numbness, breathing issues, or rash immediately.
✔️ Dosage & Administration of Umactin 50
Adults
Acute UTI:
- Standard tablets: 50–100 mg orally 4 times daily for 7 days or 3 days after sterile urine is obtained
- Sustained-release tablets (SR): 100 mg orally twice daily for 7 days or 3 days after sterile urine
- Prophylaxis: 50–100 mg orally at bedtime, up to 12 months
Children (>1 month)
- Treatment: 5–7 mg/kg/day orally, divided every 6 hours for 7 days
- Prophylaxis: 1–2 mg/kg orally at bedtime or in 2 divided doses
Age ≥12 years (SR): 100 mg orally twice daily for 7 days or 3 days post-sterility
Tablets should be taken with food to improve absorption and reduce gastrointestinal upset.
Renal Dose Adjustment
- CrCl <60 mL/min: Avoid use due to poor urinary concentration and increased toxicity risk
Monitor renal function, especially in elderly patients
✔️ Drug Interactions
- Probenecid and sulfinpyrazone: Decrease renal excretion of nitrofurantoin → risk of toxicity
- Magnesium trisilicate: Reduces absorption
- Quinolone antibiotics: Antagonistic effect
- Urinary alkalinizers or carbonic anhydrase inhibitors: Reduce efficacy
✔️ Contraindications
- Severe renal impairment (CrCl <60 mL/min)
- Known hypersensitivity to nitrofurantoin or other nitrofurans
- G6PD deficiency
- Infants <3 months of age
- Pregnancy at term (38–42 weeks), during labor and delivery
✔️ Precautions
- Elderly and those with renal, hepatic, pulmonary, or neurological disorders
- Monitor hepatic and pulmonary function during prolonged therapy
- Risk of peripheral neuropathy in patients with renal impairment, diabetes, anemia, or vitamin B deficiency
- Discontinue immediately if neuropathy or lung symptoms appear
- Avoid during breastfeeding if the infant is <1 month old
✔️ Storage:
Store in a cool and dry place away from light and heat. Keep all medicines out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
